Selected List of publications

Reddy HP, Yakubovich D, Keren-Raifman T, Tabak G, Tsemakhovich VA, Pedersen MH, Shalomov B, Colombo S, Goldstein DB, Javitch JA, Bera AK & Dascal N. (2021) Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels. iScience, 24 (9), 103018. https://doi.org/10.1016/j.isci.2021.103018.

Shalomov B, Handklo-Jamal R, Reddy HP, Theodor N, Bera AK & Dascal N. (2022). A revised mechanism of action of hyperaldosteronism-linked mutations in cytosolic domains of GIRK4 (KCNJ5). J Physiol London 600, 1419-1437. https://doi.org/10.1113/JP282690

Friesacher T, Reddy HP, Bernsteiner H, Carlo Combista J, Shalomov B, Bera AK, Zangerl-Plessl E-M, Dascal N* & Stary-Weinzinger A*. (2022). A selectivity filter mutation provides insights into gating regulation of a K⁺ channel. Communications Biology 5, 345. https://doi.org/10.1038/s42003-022-03303-1

Cui M, Xu K, Gada K, Shalomov B, Ban M, Eptaminitaki GC, Kawano T, Plant LD, Dascal N & Logothetis DE. A novel small molecule selective activator of homomeric GIRK4 channels. J Biol Chem., in press

Katz M, Subramaniam S, Chomsky-Hecht O, Tsemakhovich V, Flockerzi V, Klussmann E, Hirsch J, Weiss S & Dascal N. (2021). Reconstitution of β-adrenergic regulation of Ca_V1.2: Rad-dependent and Rad-independent protein kinase A mechanisms. Proc Natl Acad Sci USA, 118 (21), e2100021118

Handklo-Jamal, R., Meisel, E., Yakubovich, D., Vysochek, L., Beinart, R., Glikson, M., Mcmullen, J.R., Dascal, N., Nof, E., and Oz, S. (2020). Andersen–Tawil syndrome is associated with impaired PIP₂ regulation of the potassium channel Kir2.1. Front Pharmacol 11, 672 doi: 10.3389/fphar.2020.00672.

Berlin S, Artzy E, Handklo-Jamal R, Kahanovitch U, Parnas H, Dascal N & Yakubovich D. (2020). A collision coupling model governs the activation of neuronal GIRK1/2 channels by muscarinic-2 receptors. Front Pharmacol 11, 1216. doi: 10.3389/fphar.2020.01216

Tabak G, Keren-Raifman T, Kahanovitch U & Dascal N. (2019) Mutual action by Gγ and Gβ for optimal activation of GIRK channels in a channel subunit-specific manner. Sci Rep 9: 508

Keren Raifman T, Kumar P, Haase H, Klussmann E, Dascal N & Weiss S. (2017) Protein kinase C enhances plasma membrane expression of cardiac L-type calcium channel, Ca_V1.2. Channels (Austin), 11, 604-615.

Dascal N & Rubinstein M. (2017) Lithium reduces the span of G protein-activated K⁺ (GIRK) channels inhibition in hippocampal neurons. Bipolar Disord 19, 568-574.

Kahanovitch U, Berlin S & Dascal N. (2017) Collision coupling in the GABA_B receptor – G protein – GIRK signaling cascade. FEBS Lett 591, 2816-2825

Oz S, Pankonien I, Belkacemi A, Flockerzi V, Klussmann E, Haase H & Dascal N. (2017). Protein kinase A regulates C-terminally truncated Ca_V1.2 in Xenopus oocytes: roles of N- and C-termini of the α_1C subunit. J Physiol London, 595, 3181–3202.

Benmocha Guggenheimer A, Almagor L, Tsemakhovich V, Tripathy DR, Hirsch JA & Dascal N. (2016) Interactions between N and C termini of α_1C subunit regulate inactivation of Ca_V1.2 L-type Ca²⁺ channel. Channels 10, 55-68.

Yakubovich D, Berlin S, Kahanovitch U, Rubinstein M, Farhy Tselnicker I, Styr B, Keren-Raifman T, Dessauer CW & Dascal N (2015). A quantitative model of the GIRK1/2 channel reveals that its basal and evoked activities are controlled by unequal stoichiometry of Gα and Gβγ. PLoS Comput Biol 11, e1004598

Kahanovitch U, Tsemakhovich V, Berlin S, Rubinstein M, Styr B, Castel R, Peleg S, Tabak G, Dessauer CW, Ivanina T & Dascal N (2014) Recruitment of Gβγ controls the basal activity of GIRK channels: crucial role of distal C-terminus of GIRK1. J Physiol London. 592, 5373-5390 [PDF]

Farhy Tselnicker I, Tsemakhovich V, Rishal I, Kahanovitch U, Dessauer CW & Dascal N. (2014). Dual regulation of G proteins and the G-protein–activated K⁺ channels by lithium. Proc Natl Acad Sci USA 111, 5018-5023. [PDF]

Edelheit O, Ben-Shahar R, Dascal N, Hanukoglu A & Hanukoglu I. (2014). Conserved charged residues at the surface and interface of epithelial sodium channel (ENaC) subunits: roles in cell surface expression and Na⁺ self-inhibition response. FEBS J 281, 2097-2111. [PDF]

Weisbrod D, Peretz A, Ziskind A, Menaker N, Oz S, Barad L, Eliyahu S, Itskovitz-Eldor J, Dascal N, Khananshvili D, Binah O & Attali B. (2013) SK4 Ca²⁺ activated K⁺ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells. Proc Natl Acad Sci USA 110, E1685-E1694. [PDF]

Oz S, Benmocha A, Sasson Y, Sachyani D, Almagor L, Lee A, Hirsch JA & Dascal N. (2013) Competitive and non-competitive regulation of calcium-dependent inactivation in Ca_V1.2 L-type Ca²⁺ channels by calmodulin and Ca²⁺-binding protein 1. J Biol Chem 288, 12680-12691. [PDF]

Treiber F, Rosker C, Keren-Raifman T, Steinecker B, Gorischek A, Dascal N & Schreibmayer W. (2013) Molecular basis of the facilitation of the heterooligomeric GIRK1/GIRK4 complex by cAMP dependent protein kinase. Biochim Biophys Acta 1828, 1214-1221. [PDF]

Edvardson S, Oz S, Abulhijaa FA, Taher FB, Shaag A, Zenvirt S, Dascal N & Elpeleg O. (2013) Early infantile epileptic encephalopathy associated with a high voltage gated calcium channelopathy. Journal of Medical Genetics 50, 118-123. [PDF]

Almagor L, Chomsky-Hecht O, Ben Mocha A, Hendin-Barak D, Dascal N & Hirsch JA. (2012) Ca_V1.2 I-II linker structure and Timothy syndrome. Channels 6, 468-472. [PDF]

Weiss S, Keren-Raifman T, Oz S, Ben Mocha A, Haase H & Dascal N. (2012) Modulation of distinct isoforms of L-type calcium channels by G_q-coupled receptors in Xenopus oocytes: Antagonistic effects of Gβγ and protein kinase C. Channels 6, 426-437. [PDF]

Pankonien I, Otto A, Dascal N, Morano I & Haase H. (2012) Ahnak1 interaction is affected by phosphorylation of Ser-296 on Ca_Vb2. Biochem Biophys Res Commun 421, 184-189. [PDF]

Almagor L, Chomsky-Hecht O, Ben-Mocha A, Hendin-Barak D, Dascal N & Hirsch JA. (2012) The role of a voltage-dependent Ca²⁺ channel intracellular linker: a structure-function analysis. J Neurosci 32, 7602-7613. [PDF]

Berlin S, Tsemakhovich VA, Castel R, Ivanina T, Dessauer CW, Keren-Raifman T, Dascal N: Two distinct aspects of coupling between Ga_i and G protein-activated K⁺ channel (GIRK) revealed by fluorescently-labeled Ga_i3 subunits. Journal of Biological Chemistry 2011, 286:33223-33235. [PDF]

Edelheit O, Hanukoglu I, Dascal N & Hanukoglu A. (2011) Identification of the roles of conserved charged residues in the extracellular domain of an epithelial sodium channel (ENaC) subunit by alanine mutagenesis. Am J Physiol Renal Physiol 300, F887-897. [PDF]

Oz S, Tsemakhovich V, Christel CJ, Lee A, Dascal N: CaBP1 regulates voltage dependent inactivation and activation of Ca_V1.2 (L-type) calcium channels. Journal of Biological Chemistry 2011, 286:13945-13953. [PDF]

Berlin S, Keren-Raifman T, Castel R, Rubinstein M, Dessauer CW, Ivanina T, Dascal N: Ga_i and Gbg jointly regulate the conformations of a Gbg effector, the the neuronal G-protein activated K⁺ channel (GIRK). Journal of Biological Chemistry 2010, 285:6179-6185. [PDF]

Tselnicker I, Tsemakhovich VA, Dessauer CW, Dascal N: Stargazin modulates neuronal voltage-dependent Ca²⁺ channel Ca_V2.2 by a Gbg-dependent mechanism. Journal of Biological Chemistry 2010, 285(27):20462-20471. [PDF]

Benmocha A, Almagor L, Oz S, Hirsch JA, Dascal N: Characterization of the calmodulin-binding site in the N terminus of Ca_V1.2. Channels (Austin) 2009, 3(5):337-342. [PDF]

Rubinstein M, Peleg S, Berlin S, Brass D, Keren-Raifman T, Dessauer CW, Ivanina T, Dascal N: Divergent regulation of GIRK1 and GIRK2 subunits of the neuronal G protein gated K⁺ channel by Ga_iGDP and Gbg. Journal of Physiology (London) 2009, 587:3473-3491. [PDF]

Rubinstein M, Peleg S, Berlin S, Brass D, Dascal N: Ga_i3 primes the G protein-activated K⁺ channels for activation by coexpressed Gbg in intact Xenopus oocytes. Journal of Physiology (London) 2007, 581:17-32. [PDF]

Ben-Chaim Y, Chanda B, Dascal N, Bezanilla F, Parnas I, Parnas H: Movement of “gating charge” is coupled to ligand binding in a G-protein coupled receptor. Nature 2006, 444:106-109. [PDF]

Kanevsky N, Dascal N: Regulation of maximal open probability is a separable function of Ca_vb subunit in L-type Ca²⁺ channel, dependent on NH₂ terminus of a_1C (Ca_v1.2a). Journal of General Physiology 2006, 128(1):15-36. [PDF]

Rishal I, Porozov Y, Yakubovich D, Varon D, Dascal N: Gbg-dependent and Gbg-independent basal activity of G protein-activated K⁺ channels. Journal of Biological Chemistry 2005, 280(17):16685-16694. [PDF]

Blumenstein Y, Maximyuk OP, Lozovaya N, Yatsenko NM, Kanevsky N, Krishtal O, Dascal N: Intracellular Na⁺ inhibits voltage-dependent N-type Ca²⁺ channels by a G protein bg subunit-dependent mechanism. Journal of Physiology (London) 2004, 556(Pt 1):121-134. [PDF]

Ivanina T, Varon D, Peleg S, Rishal I, Porozov Y, Dessauer CW, Keren-Raifman T, Dascal N: Ga_i1 and Ga_i3 differentially interact with, and regulate, the G protein-activated K⁺ channel. Journal of Biological Chemistry 2004, 279(17):17260-17268. [PDF]

Weiss S, Doan T, Bernstein KE, Dascal N: Modulation of cardiac Ca²⁺ channel by Gq-activating neurotransmitters reconstituted in Xenopus oocytes. Journal of Biological Chemistry 2004, 279(13):12503-12510. [PDF]

Ivanina T, Rishal I, Varon D, Mullner C, Frohnwieser-Steinecke B, Schreibmayer W, Dessauer CW, Dascal N: Mapping the Gbg-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K⁺ channel. Journal of Biological Chemistry 2003, 278(31):29174-29183. [PDF]

Rishal I, Keren-Raifman T, Yakubovich D, Ivanina T, Dessauer CW, Slepak VZ, Dascal N: Na⁺ promotes the dissociation between Ga-GDP and Gbg, activating G-protein-gated K⁺ channels. Journal of Biological Chemistry 2003, 278:3840-3845. [PDF]

Blumenstein Y, Kanevsky N, Sahar G, Barzilai R, Ivanina T, Dascal N: A novel long-N-terminus isoform of human L-type Ca²⁺ channel is up-regulated by protein kinase C. J Biol Chem 2002, 277:3419-3423. [PDF]

Peleg S, Varon D, Ivanina T, Dessauer CW, Dascal N: Ga_i controls the gating of the G-protein-activated K⁺ channel, GIRK. Neuron 2002, 33:87-99. [PDF]

Ivanina T, Blumenstein Y, Shistik E, Barzilai R, Dascal N: Modulation of L-type Ca²⁺ channels by Gbg and calmodulin via interactions with N- and C-termini of a_1C. Journal of Biological Chemistry 2000, 275(51):39846-39854. [PDF]

Vorobiov D, Bera AK, Keren-Raifman T, Barzilai R, Dascal N: Coupling of the muscarinic m2 receptor to G protein-activated K⁺ channels  via Ga_z and a receptor-Ga_z fusion protein. Fusion between the receptor and Ga_z eliminates catalytic (collision) coupling. Journal of Biological Chemistry 2000, 275:4166-4170. [PDF]

Yakubovich D, Pastushenko V, Bitler A, Dessauer CW, Dascal N: Slow modal gating of single G protein-activated K⁺ channels expressed in Xenopus oocytes. Journal of Physiology (London) 2000, 524(3):737-755. [PDF]

Shistik E, Ivanina T, Blumenstein Y, Dascal N: Crucial role of N terminus in function of cardiac L-type Ca²⁺ channel and its modulation by protein kinase C. Journal of Biological Chemistry 1998, 273(28):17901-17909. [PDF]

Schreibmayer W, Dessauer CW, Vorobiov D, Gilman AG, Lester HA, Davidson N, Dascal N: Inhibition of an inwardly rectifying K channel by G-protein a– subunits. Nature 1996, 380(6575):624-627.